Калининград, Россия
сотрудник
Кемерово, Россия
Калининград, Россия
Калининград, Россия
Калининград, Россия
Калининград, Россия
Растительные экстракты являются перспективным источником новых лекарственных средств и альтернативных методов лечения. Цель данного исследования – изучить антиоксидантные и антибактериальные свойства водно-спиртовых экстрактов восточно-балтийских растений, а также их влияние на клетки крови человека. Наземные части солодки голой (Glycyrrhiza glabra L.), ивы белой (Salix alba L.), и синяка обыкновенного (Echium vulgare L.) собраны в Калининградской области (Россия). Фитохимический состав растительных экстрактов, полученных из данного растительного материала, изучался методом высокоэффективной жидкостной хроматографии (ВЭЖХ). Биологическая активность и антибактериальное действие описывались методами спектрофотометрии и диско-диффузии соответственно. Цитотоксичность экстрактов изучена с помощью колориметрического анализа WST-1. Доказано наличие в экстрактах фенольных соединений. Антиоксидантная активность экстрактов S. alba оказалась в четыре раза выше, чем у G. glabra, и более чем в семь раз превышала антиоксидантную активность экстрактов E. vulgare. Экстракты G. glabra подавляли рост как грамположительных, так и грамотрицательных бактерий, а образцы экстракта E. vulgare оказались эффективны только в отношении грамотрицательных бактерий. S. alba и E. vulgare оказались способны снижать жизнеспособность клеток Т-лимфобластного лейкоза человека (Jurkat) и мононуклеарных клеток крови. Экстракты G. glabra, S. Alba, и E. vulgare могут быть рекомендованы к использованию в области биомедицины. Требуется более подробное изучение для внедрения их в официальную медицину в качестве терапевтических и профилактических средств.
Растения, Glycyrrhiza glabra, Salix alba, Echium vulgare, водно-спиртовых экстрактов, свободные радикалы
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